Impact of Bempedoic Acid on Total Cardiovascular Events: A Prespecified Analysis of the CLEAR Outcomes Randomized Clinical Trial

SJ Nicholls, AJ Nelson, AM Lincoff, D Brennan… - … cardiology, 2024 - jamanetwork.com
… (MACE) by 13% in patients at high cardiovascular risk with … The effects of bempedoic
acid on total cardiovascular events … In summary, this prespecified analysis of the CLEAR Out…

… to maximally tolerated statins on low-density lipoprotein cholesterol in patients at high risk for cardiovascular disease: the CLEAR wisdom randomized clinical trial

AC Goldberg, LA Leiter, ESG Stroes, SJ Baum… - Jama, 2019 - jamanetwork.com
Prespecified sensitivity analyses confirmed the LDL-C … The results of this study reinforce
observations from the similarly designed CLEAR Harmony clinical trial in which bempedoic acid

[HTML][HTML] Efficacy and safety of bempedoic acid among patients with and without diabetes: prespecified analysis of the CLEAR Outcomes randomised trial

KK Ray, SJ Nicholls, N Li, MJ Louie… - The Lancet Diabetes & …, 2024 - thelancet.com
… reduced the risk of major adverse cardiovascular events … , double-blind, placebo-controlled
trial conducted across 1250 … , there was no effect of bempedoic acid treatment on HbA 1c or …

[HTML][HTML] Bempedoic acid and cardiovascular outcomes in statin-intolerant patients

SE Nissen, AM Lincoff, D Brennan… - … England Journal of …, 2023 - Mass Medical Soc
… the CLEAR (Cholesterol Lowering via Bempedoic Acid [… Results of a prespecified
subgroup analysis of the primary … The effects of bempedoic acid on cardiovascular events in …

Bempedoic acid for primary prevention of cardiovascular events in statin-intolerant patients

SE Nissen, V Menon, SJ Nicholls, D Brennan, L Laffin… - Jama, 2023 - jamanetwork.com
… a prespecified subgroup analysis of the effects of bempedoic … to perform clinical research
related to bempedoic acid; … the steering committee for CLEAR Outcomes trial. Dr Libby reported …

Effect of bempedoic acid on mortality and cardiovascular events in primary and secondary prevention: A post-hoc analysis of the CLEAR-outcomes trial

A Sayed, JM Brophy - International Journal of Cardiology, 2024 - Elsevier
… than the total number of events a patient may have experienced, which was the subject of
a recent pre-specified analysis of CLEAROutcomes showing a reduction in total events [7]. …

Major randomized clinical trials in cardiovascular disease prevention presented at the 2019 American College of Cardiology Annual Scientific Session

M Al Rifai, X Jia, MH Al-Mallah, MD Miedema… - Current atherosclerosis …, 2019 - Springer
… We discuss the clinical implications and conclude with future … bempedoic acid compared
to 10.1% in the placebo group. … events (prespecified analysis) and total endpoint events (post …

Clinical efficacy and safety outcomes of bempedoic acid for LDL-C lowering therapy in patients at high cardiovascular risk: a systematic review and meta-analysis

Y Lin, C Parco, A Karathanos, T Krieger, V Schulze… - BMJ open, 2022 - bmjopen.bmj.com
… -up, prespecified sensitivity analyses of primary clinical efficacy … -analysis of BAs efficacy for
prevention of CV events and … patients: a meta-analysis of randomized controlled trials. BMC …

Efficacy and safety of bempedoic acid in patients with hypercholesterolemia: systematic review and meta‐analysis of randomized controlled trials

A Di Minno, R Lupoli, I Calcaterra… - Journal of the …, 2020 - Am Heart Assoc
cardiovascular event, 30 this finding supports a positive effect of BA on overall cardiovascular
disease (CLEAR [Cholesterol Lowering via Bempedoic Acid, an ACL‐Inhibiting Regimen] …

Efficacy and safety of bempedoic acid in patients with hypercholesterolemia and statin intolerance

U Laufs, M Banach, GBJ Mancini… - Journal of the …, 2019 - Am Heart Assoc
… for primary or secondary prevention of cardiovascular events. … Predefined muscle‐related
adverse events occurred in 12.8… The durability of effect and safety of extended bempedoic acid